An antagonist of MCH1
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SNAP 94847

Item No. 35105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[1-[[4-(3,4-difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide
CAS Number
487051-12-7
Molecular Formula
C29H32F2N2O2
Formula Weight
478.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 25 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): insol
λmax
236 nm
SMILES
O=C(C(C)C)NC1=CC=C(C)C(C2CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C(F)=C4)F)=C1
InChi Code
InChI=1S/C29H32F2N2O2/c1-19(2)29(34)32-23-7-4-20(3)26(16-23)22-12-14-33(15-13-22)18-21-5-8-24(9-6-21)35-25-10-11-27(30)28(31)17-25/h4-11,16-17,19,22H,12-15,18H2,1-3H3,(H,32,34)
InChi Key
VMLZFUVIKCGATC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

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    25 mg

    $530

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    50 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SNAP 94847 is an antagonist of melanin-concentrating hormone receptor 1 (MHC1; Ki = 2.2 nM for the recombinant rat receptor).1 It is selective for MHC1 over α1A-adrenergic and dopamine D2 receptors (Kis = 180 and 7,400 nM, respectively, for the recombinant human receptors). SNAP 94847 (20 mg/kg) increases the time mice spend in the light side of the light/dark exploration test, indicating anxiolytic-like activity.2 It reduces food intake and body weight, as well as plasma levels of glucose, insulin, and triglycerides, in a mouse model of high-fat diet-induced obesity when administered at a dose of 5 mg/kg in combination with the cannabinoid 1 (CB1) receptor antagonist rimonabant (Item No. 9000484).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, C.-A., Jiang, Y., Lu, K., et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. J. Med. Chem. 50(16), 3883-3890 (2007).

    2. David, D.J., Klemenhagen, K.C., Holick, K.A., et al. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J. Pharmacol. Exp. Ther. 321(1), 237-248 (2007).

    3. Verty, A.N.A., Lockie, S.H., Stefanidis, A., et al. Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice. Int. J. Obes. (Lond) 37(2), 279-287 (2013).