A polycyclic aromatic hydrocarbon
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Pyrene

Item No. 35168

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
129-00-0
Synonyms
  • Benzo[def]phenanthrene
  • NSC 17534
  • NSC 66449
Molecular Formula
C16H10
Formula Weight
202.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 100 mg/ml
λmax
231, 240, 273, 319, 335 nm
SMILES
C12=CC=CC(C2=C34)=CC=C4C=CC=C3C=C1
InChi Code
InChI=1S/C16H10/c1-3-11-7-9-13-5-2-6-14-10-8-12(4-1)15(11)16(13)14/h1-10H
InChi Key
BBEAQIROQSPTKN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

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    500 g

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    Cayman Chemical
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    Product Description

    Pyrene is a polycyclic aromatic hydrocarbon (PAH).1,2 It has been found in sediments and fish in oil-contaminated mangroves and cigarette smoke. Pyrene inhibits the cytochrome P450 (CYP) isoforms CYP1A1, CYP1A2, and CYP1B1 (IC50s = 41, 7, and 2 nM).3 It has been conjugated to phospholipids to facilitate the measurement of phospholipase A2 (PLA2) activity via fluorescence.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saunders, D., Carrillo, J.C., Gundlach, E.R., et al. Analysis of polycyclic aromatic hydrocarbons (PAHs) in surface sediments and edible aquatic species in an oil-contaminated mangrove ecosystem in Bodo, Niger Delta, Nigeria: Bioaccumulation and human health risk assessment. Sci. Total Environ. 832:154802, (2022).

    2. Oyekunle, J.A.O., Afolabi, F.P., Adenuga, A.A., et al. Determination of levels of polycyclic aromatic hydrocarbons in the smoke fractions of popular cigarette brands commonly available in Nigeria. Chem. Afr. 5, 201-210 (2022).

    3. Shimada, T., Yamazaki, H., Foroozesh, M., et al. Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chem. Res. Toxicol. 11(9), 1048-1056 (1998).

    4. Radvanyi, F., Jordan, L., Russo-Marie, F., et al. A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin. Anal. Biochem. 177(1), 103-109 (1989).