A metabolite of aripiprazole
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Parent Compound(s)
19989Aripiprazole
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Aripiprazole N-oxide

Item No. 35296

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[4-[4-(2,3-dichlorophenyl)-1-oxido-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
CAS Number
573691-09-5
Synonyms
  • Aripiprazole N1-Oxide
Molecular Formula
C23H27Cl2N3O3
Formula Weight
464.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
218 nm
SMILES
O=C1NC2=CC(OCCCC[N+]3(CCN(CC3)C4=C(Cl)C(Cl)=CC=C4)[O-])=CC=C2CC1
InChi Code
InChI=1S/C23H27Cl2N3O3/c24-19-4-3-5-21(23(19)25)27-10-13-28(30,14-11-27)12-1-2-15-31-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
InChi Key
ZNYNDJDSFMRJPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $62

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    5 mg

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    10 mg

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    25 mg

    $758

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    Product Description

    Aripiprazole N-oxide is a metabolite of the atypical antipsychotic aripiprazole (Item No. 19989).1,2 It is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.3 Aripiprazole N-oxide is a potential impurity found in commercial preparations of aripiprazole.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Filijovic, N.D., Pavlović, A., Nikolic, K., et al. Validation of an HPLC method for determination of aripiprazole and its impurities in pharmaceuticals. Acta Chromatagr. 26(1), 13-28 (2014).

    2. Satyanarayana, B., Sumalatha, Y., Kumar, S.S., et al. Synthesis and characterization of N-oxides and metabolites of antipsychotic drug, aripiprazole. Heterocycl. Commun. 11(6), 485-490 (2005).

    3. Kubo, M., Koue, T., Inaba, A., et al. Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLE. Drug Metab. Pharmacokinet. 20(1), 55-64 (2005).