A modified nucleoside
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N6,N6-Dimethyladenosine

Item No. 35348

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
2620-62-4
Synonyms
  • 6-N,N-Dimethyladenosine
  • 6-DMA
  • m62A
Molecular Formula
C12H17N5O4
Formula Weight
295.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 25 mg/mLEthanol: Slightly solublePBS (pH 7.2): 2 mg/mL
λmax
216, 274 nm
SMILES
[H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(N(C)C)N=CN=C32
InChi Code
InChI=1S/C12H17N5O4/c1-16(2)10-7-11(14-4-13-10)17(5-15-7)12-9(20)8(19)6(3-18)21-12/h4-6,8-9,12,18-20H,3H2,1-2H3/t6-,8-,9-,12-/m1/s1
InChi Key
WVGPGNPCZPYCLK-WOUKDFQISA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Cayman Chemical
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    Product Description

    N6,N6-Dimethyladenosine is a modified nucleoside.1 It has been found in tRNA isolated from M. bovis. Dimethylation of adjacent adenosine nucleosides (m62Am62A) is found in E. coli 16S rRNA and is important for the initiation of protein synthesis.2 N6,N6-Dimethyladenosine inhibits the proliferation of L1210 leukemia cells in vitro (IC50 = 0.5 µg/ml) but does not have antitumor activity in vivo.2 It is also a component of the antibiotic and protein synthesis inhibitor puromycin (Item No. 13884).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chan, C.T.Y., Chionh, Y.H., Ho, C.-H., et al. Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin. Molecules 16(6), 5168-5181 (2011).

    2. Poldermans, B., Van Buul, C.P.J.J., and Van Knippenberg, P.H. Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. II. The effect of the absence of the methyl groups on initiation of protein biosynthesis. The Journal of Biological Chemisty 254(18), 9090-9093 (1979).