An active metabolite of quetiapine
Related Products
Parent Compound(s)
14152Quetiapine (hemifumarate)
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Desethoxy Quetiapine (hydrochloride)

Item No. 35410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol, dihydrochloride
CAS Number
329218-14-6
Synonyms
  • O-Desalkylquetiapine
Molecular Formula
C19H21N3OS • 2HCl
Formula Weight
412.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
OCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=CC=CC=C42.Cl.Cl
InChi Code
InChI=1S/C19H21N3OS.2ClH/c23-14-13-21-9-11-22(12-10-21)19-15-5-1-3-7-17(15)24-18-8-4-2-6-16(18)20-19;;/h1-8,23H,9-14H2;2*1H
InChi Key
OXKMTOMGUPCOBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $185

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    10 mg

    $333

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    25 mg

    $740

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    50 mg

    $1,017

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    Product Description

    Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Item No. 14152).1 It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM).2,1 Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Warawa, E.J., Migler, B.M., Ohnmacht, C.J., et al. Behavioral approach to nondyskinetic dopamine antagonists: Identification of seroquel. J. Med. Chem. 44(3), 372-389 (2001).

    2. Bakken, G.V., Rudberg, I., Christensen, H., et al. Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab. Dispos. 37(2), 254-258 (2009).