A sestrin modulator and mTORC1 activator
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NV-5138

Item No. 35482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-amino-5,5-difluoro-4,4-dimethyl-pentanoic acid
CAS Number
2095886-80-7
Molecular Formula
C7H13F2NO2
Formula Weight
181.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mM
SMILES
FC(F)C(C)(C)C[C@H](N)C(O)=O
InChi Code
InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1
InChi Key
HRFIMCJTDKEPPV-BYPYZUCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $43

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    1 mg

    $82

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    5 mg

    $215

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    10 mg

    $344

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    Product Description

    NV-5138 is a sestrin modulator and mammalian target of rapamycin protein complex 1 (mTORC1) activator.1 It binds to sestrin 2 (Kd = 1.49 µM) and induces dissociation of sestrin 2 from the multimeric mTORC1 inhibitory complex GATOR2 and mTORC1 activation when used at concentrations ranging from 30 to 100 µM. NV-5138 (40, 80, or 160 mg/kg) reduces immobility time in the forced swim test and latency to feed in the novelty-suppressed feeding test, indicating antidepressant- and anxiolytic-like activity, respectively, in rats, effects that can be reversed by the mTORC1 inhibitor rapamycin (Item No. 13346).2 It also reverses behavioral and synaptic deficits in a rat model of chronic stress-induced depression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sengupta, S., Giaime, E., Narayan, S., et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci. Rep. 9(1), 4107 (2019).

    2. Kato, T., Pothula, S., Liu, R.-J., et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J. Clin. Invest. 129(6), 2542-2554 (2019).