An active metabolite of midodrine
Related Products
Isomer(s)
15408Metanephrine
Pro-drug Form(s)
17349Midodrine (hydrochloride)
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Desglymidodrine

Item No. 35608

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(aminomethyl)-2,5-dimethoxy-benzenemethanol
CAS Number
3600-87-1
Synonyms
  • ST 1059
Molecular Formula
C10H15NO3
Formula Weight
197.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 2 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
OC(CN)C1=C(OC)C=CC(OC)=C1
InChi Code
InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
InChi Key
VFRCNXKYZVQYLX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $37

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    5 mg

    $108

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    10 mg

    $181

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    Product Description

    Desglymidodrine is the active metabolite of the prodrug midodrine (Item No. 17349).1 It is formed from midodrine by enzymatic hydrolysis.2 Desglymidodrine is an agonist of α1-adrenergic receptors (α1-ARs).1 It binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Altenbach, R.J., Khilevich, A., Kolasa, T., et al. Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing α1A-adrenoceptor agonist. J. Med. Chem. 47(12), 3220-3235 (2004).

    2. McClellan, K.J., Wiseman, L.R., and Wilde, M.I. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging 12(1), 76-86 (1998).