A metabolite of cortisol
Related Products
Isomer(s)
36224β-Cortolone
Parent Compound(s)
20739Hydrocortisone 34344Tetrahydrocortisone
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α-Cortolone

Item No. 35609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β,20S)-3,17,20,21-tetrahydroxy-pregnan-11-one
CAS Number
516-42-7
Synonyms
  • 20α-Cortolone
  • NSC 59872
Molecular Formula
C21H34O5
Formula Weight
366.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
C[C@@]12[C@](CC[C@]2(O)[C@@H](O)CO)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
InChi Code
InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17+,18-,19+,20+,21+/m1/s1
InChi Key
JXCOSKURGJMQSG-AZQJGLEESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $1,220

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    Product Description

    α-Cortolone is a metabolite of the glucocorticoid cortisol (hydrocortisone; Item No. 20739).1 It is formed from cortisol by 20α-hydroxysteroid dehydrogenase (20α-HSD) via a tetrahydrocortisone (THE; Item No. 34344) intermediate. Urinary levels of α-cortolone are decreased in patients with severe anorexia nervosa and in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Espiard, S., McQueen, J., Sherlock, M., et al. Improved urinary cortisol metabolome in Addison disease: A prospective trial of dual-release hydrocortisone. J. Clin. Endocrinol. Metab. 106(3), 814-825 (2021).

    2. Wassif, W.S., McLoughlin, D.M., Vincent, R.P., et al. Steroid metabolism and excretion in severe anorexia nervosa: Effects of refeeding. Am. J. Clin. Nutr. 93(5), 911-917 (2011).

    3. Bufa, A., Bíró, I., Poór, V., et al. Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii. Gynecol. Endocrinol. 26(1), 10-15 (2010).