A metabolite of cortisol
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β-Cortolone

Item No. 36224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,17,20R,21-tetrahydroxy-pregnan-11-one
CAS Number
667-66-3
Synonyms
  • 20β-Cortolone
  • NSC 56997
Molecular Formula
C21H34O5
Formula Weight
366.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble (warmed)Methanol: Slightly soluble (warmed)
SMILES
C[C@@]12[C@](CC[C@]2(O)[C@@H](CO)O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
InChi Code
InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17-,18-,19+,20+,21+/m1/s1
InChi Key
JXCOSKURGJMQSG-AIEJOZITSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $51

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    β-Cortolone is a metabolite of the glucocorticoid cortisol (hydrocortisone; Item No. 20739).1 It is formed from cortisol by 20β-hydroxysteroid dehydrogenase (20β-HSD) via a 5β-tetrahydrocortisol (Item No. 34195) intermediate. Urinary levels of β-cortolone are decreased in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Espiard, S., McQueen, J., Sherlock, M., et al. Improved urinary cortisol metabolome in Addison disease: A prospective trial of dual-release hydrocortisone. J. Clin. Endocrinol. Metab. 106(3), 814-825 (2021).

    2. Bufa, A., Bíró, I., Poór, V., et al. Altered urinary profiles of endogenous steroids in postmenopausal women with adenocarcinoma endometrii. Gynecol. Endocrinol. 26(1), 10-15 (2010).