Epigoitrin

Epigoitrin is an alkaloid that has been found in Crambe abyssinica and has diverse biological activities.^1,2,3,4 It decreases norepinephrine formation by bovine dopamine-β-hydroxylase in a cell-free assay when used at a concentration of 0.1 mM.¹ Epigoitrin inhibits the proliferation of RAW 264.7 macrophages (IC₅₀ = ~1 mM).² It increases serum cholesterol levels and liver and thyroid weight, as well as decreases serum thyroxine levels, in rats.³ Epigoitrin (176 mg/kg) improves survival in mice made susceptible to influenza A H1N1 infection by restraint stress.⁴ It also prolongs pentobarbital-induced sleeping time in male, but not female, rats.³

WARNING This product is not for human or veterinary use.

1. Zenker, N., Hubbard, L.S., and Wright, J. Inhibition of dopamine β-hydroxylase by goitrin, a natural antithyroid compound. J. Nat. Prod. 51(5), 862-865 (1988).

2. Hou, X., Zhang, X., Bi, J., et al. Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway. J. Nat. Med. 75(3), 602-611 (2021).

3. Nishie, K., and Daxenbichler, E. Hepatic effects of R-goitrin in Sprague-Dawley rats. Food Chem. Toxicol. 20(3), 279-287 (1982).

4. Luo, Z., Liu, L.-F., Wang, X.-H., et al. Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro. Front. Pharmacol. 10, 78 (2019).