A deoxybenzoin with diverse biological activities
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Isomer(s)
13293Rhapontigenin
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Ononetin

Item No. 35813

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-ethanone
CAS Number
487-49-0
Synonyms
  • NSC 89759
Molecular Formula
C15H14O4
Formula Weight
258.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 12 mg/mlEthanol: 12 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
214, 278 nm
SMILES
O=C(CC1=CC=C(C=C1)OC)C2=CC=C(C=C2O)O
InChi Code
InChI=1S/C15H14O4/c1-19-12-5-2-10(3-6-12)8-14(17)13-7-4-11(16)9-15(13)18/h2-7,9,16,18H,8H2,1H3
InChi Key
XHBZOAYMBBUURD-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $43

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    50 mg

    $82

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    100 mg

    $152

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    500 mg

    $547

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    Product Description

    Ononetin is a deoxybenzoin that has been found in O. spinosa and has diverse biological activities.1,2 It is an inhibitor of transient receptor potential melastatin 3 (TRPM3; IC50 = 0.3 µM for the mouse receptor).1 Ononetin scavenges DPPH (Item No. 14805), ABTS (Item No. 27317), and superoxide anion radicals in cell-free assays (IC50s = 57.4, 62.64, and 35.19 µM, respectively).2 It also inhibits mushroom tyrosinase activity with an IC50 value of 78.88 µM after 30 minutes. Ononetin (10 mg/kg) reverses heat hypersensitivity induced by complete Freund’s adjuvant in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Straub, I., Mohr, F., Stab, J., et al. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br. J. Pharmacol. 168(8), 1835-1850 (2013).

    2. Ng, L.-T., Ko, H.-H., and Lu, T.-M. Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. Bioorg. Med. Chem. 17(13), 4360-4366 (2009).

    3. Alkhatib, O., da Costa, R., Gentry, C., et al. Promiscuous G-protein-coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by Gβγ subunits. J. Neurosci. 39(40), 7840-7852 (2019).