A sesquiterpene with diverse biological activities
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Atractylenolide II

Item No. 36173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4aS,5,6,7,8,8aR,9,9aS-octahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan-2(4H)-one
CAS Number
73069-14-4
Synonyms
  • 2-Atractylenolide
Molecular Formula
C15H20O2
Formula Weight
232.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.3 mg/ml
λmax
219 nm
SMILES
C[C@]12[C@@](C(CCC2)=C)([H])CC([C@](O3)([H])C1)=C(C)C3=O
InChi Code
InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h12-13H,1,4-8H2,2-3H3/t12-,13-,15+/m0/s1
InChi Key
OQYBLUDOOFOBPO-KCQAQPDRSA-N
Origin
Plant/Atractylodes macrocephala
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    Atractylenolide II is a sesquiterpene that has been found in D. metel and has diverse biological activities.1,2,3 It inhibits proliferation of, as well as halts the cell cycle at the G2/M phase and induces apoptosis in, DU145 and LNCaP prostate cancer cells when used at concentrations of 50 and 100 µM.1 Atractylenolide II also inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC50 = 17.73 µM).2 It increases Nrf2 protein levels when used at a concentration of 50 µM and reduces reactive oxygen species (ROS) production induced by irradiation in HaCaT cells.3 Atractylenolide II (60 mg/kg) prevents cutaneous and intestinal ulcers induced by irradiation in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, J., Nasser, M.I., Adlat, S., et al. Atractylenolide II induces apoptosis of prostate cancer cells through regulation of AR and JAK2/STAT3 signaling pathways. Molecules 23(12), 3298 (2018).

    2. Tan, J.-Y., Liu, Y., Cheng, Y.-G., et al. Anti-inflammatory sesquiterpenoids from the leaves of Datura metel L. Fitoterapia 142, 104531 (2020).

    3. Xiao, C., Xu, C., He, N., et al. Atractylenolide II prevents radiation damage via MAPKp38/Nrf2 signaling pathway. Biochem. Pharmacol. 177, 114007 (2020).