A flavanone with diverse biological activities
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Fustin

Item No. 36273

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3R)-rel-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4H-1-benzopyran-4-one
CAS Number
20725-03-5
Synonyms
  • Dihydrofisetin
  • NSC 59264
Molecular Formula
C15H12O6
Formula Weight
288.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleDichloromethane: solubleDMSO: solubleEthyl Acetate: soluble
SMILES
OC(C=CC([C@H]1OC2=CC(O)=CC=C2C([C@@H]1O)=O)=C3)=C3O
InChi Code
InChI=1S/C15H12O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,14-18,20H/t14-,15+/m0/s1
InChi Key
FNUPUYFWZXZMIE-LSDHHAIUSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $118

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    10 mg

    $156

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    25 mg

    $349

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    Cayman Chemical
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    Product Description

    Fustin is a polyketide synthase-derived flavanone that has been found in R. verniciflua and has diverse biological activities.1,2,3,4 It enhances epigallocatechin-3-O-gallate-induced decreases in the viability of U266 multiple myeloma cells when used at concentrations of 5 and 10 µM.2 Fustin (50 and 100 mg/kg) inhibits increases in blood glucose levels, as well as serum total cholesterol, triglyceride, and malondialdehyde (MDA) levels, in a mouse model of diabetes induced by streptozotocin (Item No. 13104).3 It prevents decreases in contextual- and tone fear conditioning freezing time, indicating a reversal of memory deficits, induced by amyloid-β (1-42) (Aβ42) in mice when administered at a dose of 100 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marín, L., Gutiérrez-Del-Río, I., Villar, C.J., et al. De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity. Microb. Biotechnol. 14(5), 2009-2024 (2021).

    2. Kumazoe, M., Fujimura, Y., Yoshitomi, R., et al. Fustin, a flavanonol, synergically potentiates the anticancer effect of green tea catechin epigallocatechin-3-O-gallate with activation of the eNOS/cGMP axis. J. Agric. Food Chem. 70(11), 3458-3466 (2022).

    3. Gilani, S.J., Bin-Jumah, M.N., Al-Abbasi, F.A., et al. Fustin ameliorates hyperglycemia in streptozotocin induced type-2 diabetes via modulating glutathione/superoxide dismutase/catalase expressions, suppress lipid peroxidation and regulates histopathological changes. Saudi J. Biol. Sci. 28(12), 6963-6971 (2021).

    4. Jin, C.-H., Shin, E.-J., Park, J.-B., et al. Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment. J. Neurosci. Res. 87(16), 3658-3670 (2009).