An inhibitor of COMT and tyrosine hydroxylase
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Isomer(s)
37417Propylparaben
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U-0521

Item No. 36314

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone
CAS Number
5466-89-7
Synonyms
  • 3′,4′-Dihydroxy-2-methylpropiophenone
  • NSC 27389
Molecular Formula
C10H12O3
Formula Weight
180.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/ml
λmax
231, 277, 308 nm
SMILES
O=C(C(C)C)C1=CC=C(C(O)=C1)O
InChi Code
InChI=1S/C10H12O3/c1-6(2)10(13)7-3-4-8(11)9(12)5-7/h3-6,11-12H,1-2H3
InChi Key
VDQLKIBLTMPAHI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $107

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    50 mg

    $204

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    100 mg

    $321

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    U-0521 is an inhibitor of catechol-O-methyltransferase (COMT; Ki = 7.8 µM for the rat liver enzyme) and tyrosine hydroxylase (IC50 = 1 µM for the rabbit adrenal enzyme).1,2 It enhances epinephrine-induced contractions of isolated rabbit atria when used at a concentration of 55 µM.1 U-0521 (41.5 µmol/kg) also enhances isoprenaline- or epinephrine-induced increases in blood glucose levels in pancreatectomized rats.3 It decreases blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at a dose of 50 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giles, R.E., and Miller, J.W. A comparison of certain properties of catechol-O-methyl transferase to those of adrenergic beta receptors. J. Pharmacol. Exp. Ther. 156(2), 201-206 (1967).

    2. Lloyd, T., Boyd, B., Walega, M.A., et al. A comparison of 2-hydroxyestradiol and U-0521 (3'4'-dihydroxy-2-methylpropiophenone, Upjohn) as in situ and in vitro inhibitors of tyrosine hydroxylase. J. Neurochem. 38(4), 948-954 (1982).

    3. Proença, J., and Guimarães, S. Influence of inhibition of extraneuronal uptake and of O-methylation on the hyperglycaemia caused by sympathomimetic amines in depancreatized rats. J. Pharm. Pharmacol. 44(2), 139-141 (1992).

    4. Lloyd, T., and Waldman, C.D. The antihypertensive effect of U-0521 (3',4'-dihydroxy-2-methylpropiophenone). Life Sci. 31(19), 2121-2127 (1982).