An internal standard for the quantification of uridine
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Unlabeled Version(s)
20300Uridine
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Uridine-d2

Item No. 36317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
uridine-5,6-d2
CAS Number
40632-21-1
Synonyms
  • 1-β-D-Ribofuranosyluracil-d2
  • Uracil-1-β-D-ribofuranoside-d2
  • β-Uridine-d2
Molecular Formula
C9H10D2N2O6
Formula Weight
246.2
Purity
≥99% deuterated forms (d1-d2)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O[C@H]1[C@@](N2C(NC(C([2H])=C2[2H])=O)=O)([H])O[C@@H]([C@H]1O)CO
InChi Code
InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1/i1D,2D
InChi Key
DRTQHJPVMGBUCF-SXFMXZDVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Uridine-d2 is intended for use as an internal standard for the quantification of uridine (Item No. 20300) by GC- or LC-MS. Uridine is a pyrimidine nucleoside composed of uracil (Item No. 26088) and ribose.1 It forms complementary base pairs with adenosine (Item No. 21232) in RNA.2 Uridine can be catabolized to uracil via uridine phosphorylase, and it can be phosphorylated to uridine-5'-monophosphate (UMP; Item No. 35382) by uridine-cytidine kinase (UCK).1,3 It is replaced with thymidine (Item No. 20519) in DNA.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamamoto, T., Koyama, H., Kurajoh, M., et al. Biochemistry of uridine in plasma. Clin. Chim. Acta 412(19-20), 1712-1724 (2011).

    2. Zinshteyn, B., and Nishikura, K. Adenosine-to-inosine RNA editing. Wiley Interdiscip. Rev. Syst. Biol. Med. 1(2), 202-209 (2009).

    3. Van Rompay, A.R., Norda, A., Lindén, K., et al. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol. Pharmacol. 59(5), 1181-1186 (2001).

    4. Knoop, V. When you can't trust the DNA: RNA editing changes transcript sequences. Cell. Mol. Life Sci. 68(4), 567-586 (2011).