An internal standard for the quantification of thymidine
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Unlabeled Version(s)
20519Thymidine
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Thymidine-d4

Item No. 36322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
thymidine-α,α,α,6-d4
CAS Number
347841-67-2
Synonyms
  • dT-d4
  • 5-Methyldeoxyuridine-d4
  • Thymine deoxyriboside-d4
  • 2'-deoxy Thymidine-d4
  • 2'-deoxy-5-methyl-Uridine-d4
Molecular Formula
C10H10D4N2O5
Formula Weight
246.3
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mLDMSO: 10mg/mLPBS (pH 7.2): 5mg/mL
SMILES
OC[C@H]1O[C@](N2C(NC(C(C([2H])([2H])[2H])=C2[2H])=O)=O)([H])C[C@@H]1O
InChi Code
InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1/i1D3,3D
InChi Key
IQFYYKKMVGJFEH-BTDYSWPSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $110

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    5 mg

    $469

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    Product Description

    Thymidine-d4 is intended for use as an internal standard for the quantification of thymidine (Item No. 20519) by GC- or LC-MS. Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base.1 It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate (dTMP; Item No. 33549).2 Oral administration of thymidine in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Biochemistry. (2002).

    2. Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al. Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency. Ann. Neurol. 81(5), 641-652 (2017).