An internal standard for the quantification of olmesartan
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Unlabeled Version(s)
23412Olmesartan
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Olmesartan-d6

Item No. 36324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-hydroxy-1-(methyl-d3)ethyl-2,2,2-d3]-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
CAS Number
1185144-74-4
Molecular Formula
C24H20D6N6O3
Formula Weight
452.5
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C1=C(C(O)=O)N(CC(C=C2)=CC=C2C3=C(C4=NN=NN4)C=CC=C3)C(CCC)=N1
InChi Code
InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)/i2D3,3D3
InChi Key
VTRAEEWXHOVJFV-XERRXZQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Olmesartan-d6 is intended for use as an internal standard for the quantification of olmesartan (Item No. 23412) by GC- or LC-MS. Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil (Item No. 11614).1 It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma.2 Olmesartan is selective for AT1 over AT2 (IC50 = >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II (Item No. 17150; pD2 = 9.9) but not phenylephrine (Item Nos. 17205 | 18619) or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizuno, M., Sada, T., Ikeda, M., et al. Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. Eur. J. Pharmacol. 285(2), 181-188 (1995).

    2. Ishizuka, T., Fujimori, I., Nishida, A., et al. Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: Molecular identification and contribution to plasma metabolism. Drug Metab. Dispos. 40(2), 374-380 (2012).