An immunomodulator and a derivative of forphenicine
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Isomer(s)
13249D-DOPA 13248L-DOPA
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Forphenicinol

Item No. 36382

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-amino-3-hydroxy-4-(hydroxymethyl)-benzeneacetic acid
CAS Number
71522-58-2
Synonyms
  • Forfenimex
Molecular Formula
C9H11NO4
Formula Weight
197.2
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: solubleWater: soluble
SMILES
OC([C@H](C1=CC(O)=C(C=C1)CO)N)=O
InChi Code
InChI=1S/C9H11NO4/c10-8(9(13)14)5-1-2-6(4-11)7(12)3-5/h1-3,8,11-12H,4,10H2,(H,13,14)/t8-/m0/s1
InChi Key
JRBXPUUAYKCCLQ-QMMMGPOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $370

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    1 mg

    $665

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    Product Description

    Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine (Item No. 33504).1 It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 µg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 µg/animal) increases survival in a mouse model of P. aeruginosa infection.3 It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishizuka, M., Ishizeki, S., Masuda, T., et al. Studies on effects of forphenicinol on immune responses. J. Antibiot. (Tokyo) 35(8), 1042-1048 (1982).

    2. Naito, K., Arakawa, H., Watanabe, Y., et al. Protective effect of forphenicinol, a low molecular weight immunomodifier, against infection with Pseudomonas aeruginosa in mice and its mechanisms. J. Antibiot. (Tokyo) 40(4), 547-545 (1987).

    3. Ishizuka, M., Masuda, T., Kanbayashi, N., et al. Antitumor effect of forphenicinol, a low molecular weight immunomodifier, on murine transplantable tumors and microbial infections. J. Antibiot. (Tokyo) 35(8), 1049-1054 (1982).