An sEH inhibitor
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t-TUCB

Item No. 36384

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[trans-4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]-benzoic acid
CAS Number
948304-40-3
Molecular Formula
C21H21F3N2O5
Formula Weight
438.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
247 nm
SMILES
FC(F)(F)OC(C=C1)=CC=C1NC(N[C@H](CC2)CC[C@@H]2OC3=CC=C(C=C3)C(O)=O)=O
InChi Code
InChI=1S/C21H21F3N2O5/c22-21(23,24)31-18-11-5-15(6-12-18)26-20(29)25-14-3-9-17(10-4-14)30-16-7-1-13(2-8-16)19(27)28/h1-2,5-8,11-12,14,17H,3-4,9-10H2,(H,27,28)(H2,25,26,29)/t14-,17-
InChi Key
XDVFKCZZXOGEMN-CZIWCDLHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $79

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    10 mg

    $148

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    25 mg

    $272

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    Product Description

    t-TUCB is a soluble epoxide hydrolase (sEH) inhibitor (IC50s = 0.4, 3.1, and 11.9 nM for the human, mouse, and rat enzymes, respectively).1 It also inhibits fatty acid amide hydrolase (FAAH; IC50 = 260 nM for the human enzyme). t-TUCB (3 mg/kg) increases the mechanical paw withdrawal threshold in a mouse model of diabetic neuropathic pain induced by streptozotocin (Item No. 13104).1 It prevents EKG abnormalities induced by the β1- and β2-adrenergic receptor agonist isoproterenol (Item No. 15592), as well as reduces isoproterenol-induced increases in infarct size and heart weight, in a rat model of myocardial ischemia when administered at doses of 3, 10, and 30 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sasso, O., Wagner, K., Morisseau, C., et al. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol. Res. 97, 7-15 (2015).

    2. Ayush, S., Krishnamurthy, P.T., Thomas, P., et al. Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats. J. Pharm. Pharmacol. 66(9), 1251-1258 (2014).