A peptide antagonist of CRF2α and CRF2β
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K 41498 (trifluoroacetate salt)

Item No. 36417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-alanyl-L-asparaginyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-aspartyl-L-threonyl-L-isoleucinamide, trifluoroacetate salt
Molecular Formula
C162H276N48O46 • XCF3COOH
Formula Weight
3632.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
FHLLRKXIEIEKQEKEKQQAANNRLLLDTI-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C([C@@H](CC1=CC=CC=C1)N[H])N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCC)C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([H])(C(N[C@@]([H])([C@H](CC)C)C(N)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)=O)=O)CCCCN[H])=O)CCCNC(N)=N)=O)=O)=O)CC2=CNC=N2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C162H276N48O46.C2HF3O2/c1-21-25-41-94(184-136(232)95(42-29-33-62-163)185-140(236)99(46-37-66-179-161(174)175)189-149(245)108(68-80(5)6)201-152(248)111(71-83(11)12)204-154(250)113(74-92-78-178-79-181-92)199-134(230)93(167)73-91-39-27-26-28-40-91)147(243)208-128(86(16)23-3)159(255)197-107(54-61-125(223)224)148(244)209-129(87(17)24-4)158(254)196-106(53-60-124(221)222)146(242)188-97(44-31-35-64-165)138(234)193-103(50-57-119(170)214)143(239)195-105(52-59-123(219)220)145(241)187-98(45-32-36-65-166)139(235)194-104(51-58-122(217)218)144(240)186-96(43-30-34-63-164)137(233)192-102(49-56-118(169)213)142(238)191-101(48-55-117(168)212)135(231)183-88(18)132(228)182-89(19)133(229)198-114(75-120(171)215)156(252)205-115(76-121(172)216)155(251)190-100(47-38-67-180-162(176)177)141(237)200-109(69-81(7)8)150(246)202-110(70-82(9)10)151(247)203-112(72-84(13)14)153(249)206-116(77-126(225)226)157(253)210-130(90(20)211)160(256)207-127(131(173)227)85(15)22-2;3-2(4,5)1(6)7/h26-28,39-40,78-90,93-116,127-130,211H,21-25,29-38,41-77,163-167H2,1-20H3,(H2,168,212)(H2,169,213)(H2,170,214)(H2,171,215)(H2,172,216)(H2,173,227)(H,178,181)(H,182,228)(H,183,231)(H,184,232)(H,185,236)(H,186,240)(H,187,241)(H,188,242)(H,189,245)(H,190,251)(H,191,238)(H,192,233)(H,193,234)(H,194,235)(H,195,239)(H,196,254)(H,197,255)(H,198,229)(H,199,230)(H,200,237)(H,201,248)(H,202,246)(H,203,247)(H,204,250)(H,205,252)(H,206,249)(H,207,256)(H,208,243)(H,209,244)(H,210,253)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H4,174,175,179)(H4,176,177,180);(H,6,7)/t85-,86-,87-,88-,89-,90+,93+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,127-,128-,129-,130-;/m0./s1
InChi Key
KDCMDFVMLNEQBZ-PVYGMQBSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $168

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    1 mg

    $318

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    5 mg

    $1,505

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    Product Description

    K 41498 is a peptide antagonist of corticotropin-releasing factor receptor 2α (CRF2α) and CRF2β (Kis = 0.66 and 0.62 nM, respectively, in HEK293 cells expressing the human receptors).1 It is selective for CRF2α and CRF2β over CRF1 (Ki = 425 nM in HEK293 cells expressing the human receptor). K 41498 (1.84 µg/animal, i.v.) prevents hypotension induced by urocortin (Item No. 24745) in rats. Intrathecal administration of K 41498 (0.075-0.5 µmol/animal) decreases the mechanical paw withdrawal threshold in a rat model of nociception induced by complete Freund's adjuvant.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lawrence, A.J., Krstew, E.V., Dautzenberg, F.M., et al. The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Br. J. Pharmacol. 136(6), 896-904 (2002).

    2. Mousa, S.A., Shaqura, M., Khalefa, B.I., et al. Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief. Mol. Neurobiol. 58(11), 5459-5472 (2021).