A modified nucleoside
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2′-O-Methyluridine

Item No. 36520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-O-methyl-uridine
CAS Number
2140-76-3
Synonyms
  • 2'-O-methyl UR
  • 1-(2′-O-methyl-β-D-ribofuranosyl)-Uracil
Molecular Formula
C10H14N2O6
Formula Weight
258.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 12 mg/mlEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
λmax
263 nm
SMILES
CO[C@H]1[C@@](N(C=CC2=O)C(N2)=O)([H])O[C@H](CO)[C@H]1O
InChi Code
InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1
InChi Key
SXUXMRMBWZCMEN-ZOQUXTDFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    5 g

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    10 g

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    25 g

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    Cayman Chemical
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    Product Description

    2′-O-Methyluridine is a modified nucleoside that has been found in T. thermophila tRNA.1 Incorporation of 2′-O-methyluridine into siRNA targeting the gene encoding apolipoprotein B (ApoB) decreases ApoB protein levels in HepG2 cells and prevents the production of IFN-α in isolated human peripheral blood mononuclear cells (PBMCs) compared with siRNA containing only native nucleosides.2 Serum levels of 2′-O-methyluridine are decreased in patients with breast cancer.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuchino, Y., Hanyu, N., Tashiro, F., et al. Tetrahymena thermophila glutamine tRNA and its gene that corresponds to UAA termination codon. Proc. Natl. Acad. Sci. USA 82(14), 4758-4762 (1985).

    2. Judge, A.D., Bola, G., Lee, A.C.H., et al. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13(3), 494-505 (2006).

    3. Fang, Z., Hu, Y., Chen, J., et al. Mass spectrometry-based targeted serum monomethylated ribonucleosides profiling for early detection of breast cancer. Front. Mol. Biosci. 8, 741603 (2021).