An FGF2 mimetic
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SUN11602

Item No. 36572

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-benzamide
CAS Number
704869-38-5
Molecular Formula
C26H37N5O2
Formula Weight
451.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C1=CC=C(CN2CCC(CC2)N(C)C(CNC3=C(C)C(C)=C(N)C(C)=C3C)=O)C=C1)N
InChi Code
InChI=1S/C26H37N5O2/c1-16-18(3)25(19(4)17(2)24(16)27)29-14-23(32)30(5)22-10-12-31(13-11-22)15-20-6-8-21(9-7-20)26(28)33/h6-9,22,29H,10-15,27H2,1-5H3,(H2,28,33)
InChi Key
KCODNOOPOPTZMO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    SUN11602 is a mimetic of FGF2, also known as basic FGF (bFGF).1 It protects against glutamate-induced toxicity in primary rat cortical neurons when used at concentrations of 0.1, 0.3, and 1 µM, an effect that can be reversed by the FGFR1 inhibitor PD 166866 (Item No. 22464). SUN11602 (1 µM) stimulates neurite outgrowth in primary rat hippocampal neurons.2 It reduces cognitive deficits induced by injection of aggregated amyloid-β (1-40) (Aβ40) and ibotenic acid (Item No. 14584) into the hippocampus in a rat model of Alzheimer’s disease when administered at a dose of 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murayama, N., Kadoshima, T., Takemoto, N., et al. SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. ACS Chem. Neurosci. 4(2), 266-276 (2012).

    2. Ogino, R., Murayama, N., Noshita, T., et al. SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer’s disease induced by amyloid β and excitatory amino acids. Brain Res. 1585, 159-166 (2014).