An inhibitor of FTO
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Active Metabolite(s)
37383FB23
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FB23-2

Item No. 36606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-benzamide
CAS Number
2243736-45-8
Molecular Formula
C18H15Cl2N3O3
Formula Weight
392.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleMethanol: Slightly soluble
λmax
216 nm
SMILES
O=C(C1=C(NC2=C(C=C(C3=C(C)ON=C3C)C=C2Cl)Cl)C=CC=C1)NO
InChi Code
InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
InChi Key
ILHNIWOZZKIBNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    FB23-2 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 2.6 µM).1 It reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively). FB23-2 increases m6A levels in isolated human bone marrow cells, as well as suppresses the proliferation of isolated human bone marrow cells and a panel of acute myeloid leukemia (AML) cells (IC50s = 1.9-5.2 µM). In vivo, FB23-2 (2 mg/kg) delays disease onset and increases survival in a Mono-Mac-6 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Y., Su, R., Sheng, Y., et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell 35(4), 677-691.e610 (2019).