An active metabolite of amitriptyline and nortriptyline
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trans-10-hydroxy Nortriptyline

Item No. 36660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5E)-10,11-dihydro-5-[3-(methylamino)propylidene]-5H-dibenzo[a,d]cyclohepten-10-ol
CAS Number
47132-16-1
Synonyms
  • 10(E)-hydroxy Nortriptyline
Molecular Formula
C19H21NO
Formula Weight
279.4
Purity
≥90%
Formulation (Request formulation change)
A semi-solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlChloroform: Sparingly soluble: 1-10 mg/ml
SMILES
CNCC/C=C1C2=CC=CC=C2C(CC3=CC=CC=C3/1)O
InChi Code
InChI=1S/C19H21NO/c1-20-12-6-11-16-15-8-3-2-7-14(15)13-19(21)18-10-5-4-9-17(16)18/h2-5,7-11,19-21H,6,12-13H2,1H3/b16-11+
InChi Key
VAGXZGJKNUNLHK-LFIBNONCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    trans-10-hydroxy Nortriptyline is an active metabolite of the tricyclic antidepressants amitriptyline (Item No. 15881) and nortriptyline (Item No. 15904).1,2 It is formed from amitriptyline and nortriptyline by the cytochrome P450 (CYP) isoform CYP2D6.1 trans-10-hydroxy Nortriptyline inhibits norepinephrine reuptake in rat cortical slices and isolated human plasma (EC50s = 160 and 176 nM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coutts, R.T., Bach, M.V., and Baker, G.B. Metabolism of amitriptyline with CYP2D6 expressed in a human cell line. Xenobiotica 27(1), 33-47 (1997).

    2. Bertilsson, l., Mellström, B., and Sjöqvist, F. Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline. Life Sci. 25(15), 1285-1292 (1979).