An ionizable cationic lipid
Related Products
Isomer(s)
38885(S)-C12-200 36699C12-200
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(R)-C12-200

Item No. 43647

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,2′R)-1,1′-[[2-[4-[2-[[2-[bis[(2R)-2-hydroxydodecyl]amino]ethyl][(2R)-2-hydroxydodecyl]amino]ethyl]-1-piperazinyl]ethyl]imino]bis-2-dodecanol
CAS Number
1226777-45-2
Synonyms
  • KB-R12
Molecular Formula
C70H145N5O5
Formula Weight
1137.0
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O[C@H](CCCCCCCCCC)CN(CCN(C[C@@H](CCCCCCCCCC)O)C[C@@H](CCCCCCCCCC)O)CCN1CCN(CCN(C[C@@H](CCCCCCCCCC)O)C[C@@H](CCCCCCCCCC)O)CC1
InChi Code
InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3/t66-,67-,68-,69-,70-/m1/s1
InChi Key
RVHYPUORVDKRTM-ZSTXVYJSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $207

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    25 mg

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    50 mg

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    Product Description

    (R)-C12-200 is an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200 (Item No. 36699) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 Intravenous administration of LNPs containing (R)-C12-200 and encapsulating mRNA encoding Cre recombinase increases the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice to a lesser extent than LNPs containing (S)-C12-200 (Item No. 38885) and encapsulating Cre recombinase. LNPs containing (R)-C12-200 and encapsulating mRNA encoding purine nucleoside phosphorylase (PNP), an E. coli enzyme that converts fludarabine phosphate (Item No. 14251) into the cytotoxic agent 2-fluoroadenine, induce intratumoral expression of PNP and reduce tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when co-administered with fludarabine phosphate.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Da Silva Sanchez, A.J., Zhao, K., Huayamares, S.G., et al. Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery. J. Control Release 353, 270-277 (2023).

    2. Huayamares, S.G., Lian, L., Rab, R., et al. Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses. Nat. Commun. 16(1), 3490 (2025).