An ionizable cationic lipid
Related Products
Isomer(s)
43647(R)-C12-200 36699C12-200
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(S)-C12-200

Item No. 38885

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-[[2-[4-[2-[[2-[bis[(2S)-2-hydroxydodecyl]amino]ethyl][(2S)-2-hydroxydodecyl]amino]ethyl]-1-piperazinyl]ethyl]imino]bis-2-dodecanol
CAS Number
1226552-44-8
Synonyms
  • C12-200-S
Molecular Formula
C70H145N5O5
Formula Weight
1137.0
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
O[C@@H](CCCCCCCCCC)CN(CCN(C[C@H](CCCCCCCCCC)O)C[C@H](CCCCCCCCCC)O)CCN1CCN(CCN(C[C@H](CCCCCCCCCC)O)C[C@H](CCCCCCCCCC)O)CC1
InChi Code
InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3/t66-,67-,68-,69-,70-/m0/s1
InChi Key
RVHYPUORVDKRTM-NQSOBCIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $207

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    50 mg

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    Product Description

    (S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200 (Item No. 36699).1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intravenous administration of LNPs containing (S)-C12-200 and encapsulating mRNA encoding Cre recombinase increase the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice greater than (R)-C12-200-containing and Cre mRNA-encapsulating LNPs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Da Silva Sanchez, A.J., Zhao, K., Huayamares, S.G., et al. Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery. J. Control Release 353, 270-277 (2023).