A dual inhibitor of p70S6K and Akt1
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M2698

Item No. 36816

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(1S)-2-(1-azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]-8-quinazolinecarboxamide
CAS Number
1379545-95-5
Synonyms
  • MSC2363318A
Molecular Formula
C21H19ClF3N5O
Formula Weight
449.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
FC(F)(F)C(C=C1[C@@H](CN2CCC2)NC3=NC=NC4=C3C=CC=C4C(N)=O)=C(C=C1)Cl
InChi Code
InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1
InChi Key
HXAUJHZZPCBFPN-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $218

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    10 mg

    $387

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    25 mg

    $845

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    Product Description

    M2698 is a dual inhibitor of p70 ribosomal S6 kinase (p70S6K) and Akt1 (IC50s = 1.1 and 4 nM, respectively).1 It is selective for p70S6K and Akt1 over Aurora B kinase (IC50 = 170 nM), as well as a panel of 265 kinases at 1 µM, but also inhibits protein kinase A (PKA), p90 ribosomal S6 kinase 1 (MSK1), MSK2, cGMP-dependent protein kinase 1α (PKG1α), PKG1β, and protein kinase X (PRKX). M2698 reduces tumor volume in MiaPaCa-2 pancreatic cancer and A549 non-small cell lung cancer (NSCLC) mouse xenograft models when administered at doses of 20 or 30 mg/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. DeSelm, L., Huck, B., Lan, R., et al. Identification of clinical candidate M2698, a dual p70S6K and Akt inhibitor, for treatment of PAM pathway-altered cancers. J. Med. Chem. 64(19), 14603-14619 (2021).