An antagonist of GHS-R1a
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[D-Lys3]-GHRP-6 (trifluoroacetate salt)

Item No. 36862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-6-amino-2-((R)-2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)-3-(1H-indol-3-yl)propanamido)-N-((S)-1-(((R)-1-(((S)-1,6-diamino-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)hexanamide, trifluoroacetate salt
Synonyms
  • [D-Lys3]-Growth Hormone Releasing Peptide 6
  • His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2
Molecular Formula
C49H63N13O6 • XCF3COOH
Formula Weight
930.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
218 nm
SMILES
OC(C(F)(F)F)=O.NCCCC[C@@H](C(N)=O)NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](CCCCN)NC([C@H](NC([C@@H](N)CC2=CN=CN2)=O)CC3=CNC4=CC=CC=C34)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O
InChi Code
InChI=1S/C49H63N13O6.C2HF3O2/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33;3-2(4,5)1(6)7/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65);(H,6,7)/t36-,39-,40+,41+,42+,43-;/m0./s1
InChi Key
FCNASYYZYRXDIS-CLEXWJBOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    [D-Lys3]-GHRP-6 is an antagonist of the growth hormone secretagogue receptor 1a (GHS-R1a; Ki = 4.25 nM).1 It inhibits ghrelin-induced cAMP accumulation in human aortic smooth muscle cells when used at a concentration of 20 nM. [D-Lys3]-GHRP-6 (12 mg/kg) decreases food intake in Zucker FA/FA lean and fa/fa obese rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rossi, F., Castelli, A., Bianco, M.J., et al. Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activation. Atherosclerosis 203(1), 97-104 (2008).

    2. Beck, B., Richy, S., and Sticker-Krongrad, A. Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sci. 76(4), 473-478 (2004).