A PEGylated form of DSPE
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DSPE-mPEG(2000) (sodium salt)

Item No. 37148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-poly(oxy-1,2-ethanediyl), monosodium salt
CAS Number
247925-28-6
Synonyms
  • 1,2-Dioctadecanoyl-sn-glycero-3-Phosphoethanolamine-N-mPEG(2000)
  • 1,2-Distearoyl Phosphatidylethanolamine-N-mPEG(2000)
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-methoxy-Polyethylene Glycol-2000
  • 1,2-DSPE-mPEG(2000)
  • PE(18:0/18:0)-mPEG(2000)
  • PtdEtn-(1,2-Distearoyl)-N-mPEG(2000)
Molecular Formula
(C2H4O)nC43H83NO10P • Na
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleWater: Slightly soluble
SMILES
COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC(NCCOP(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])=O)=O.[Na+]
InChi Code
InChI=1S/C221H440NO99P.Na/c1-5-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-218(223)317-214-217(321-219(224)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-6-2)215-320-322(226,227)319-39-38-222-221(225)318-216-220(315-212-210-313-208-206-311-204-202-309-200-198-307-196-194-305-192-190-303-188-186-301-184-182-299-180-178-297-176-174-295-172-170-293-168-166-291-164-162-289-160-158-287-156-154-285-152-150-283-148-146-281-144-142-279-140-138-277-136-134-275-132-130-273-128-126-271-123-122-269-119-118-267-115-114-265-111-110-263-107-106-261-103-102-259-99-98-257-95-94-255-91-90-253-87-86-251-83-82-249-79-78-247-75-74-245-71-70-243-67-66-241-63-62-239-59-58-237-55-54-235-51-50-233-47-46-231-43-42-229-7-3)316-213-211-314-209-207-312-205-203-310-201-199-308-197-195-306-193-191-304-189-187-302-185-183-300-181-179-298-177-175-296-173-171-294-169-167-292-165-163-290-161-159-288-157-155-286-153-151-284-149-147-282-145-143-280-141-139-278-137-135-276-133-131-274-129-127-272-125-124-270-121-120-268-117-116-266-113-112-264-109-108-262-105-104-260-101-100-258-97-96-256-93-92-254-89-88-252-85-84-250-81-80-248-77-76-246-73-72-244-69-68-242-65-64-240-61-60-238-57-56-236-53-52-234-49-48-232-45-44-230-41-40-228-4;/h217,220H,5-216H2,1-4H3,(H,222,225)(H,226,227);/q;+1/p-1/t217-,220?;/m1./s1
InChi Key
MDBBDFMSMPHWGY-VJEKXSTHSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

    $279

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    50 mg

    $512

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    Product Description

    DSPE-mPEG(2000) is a PEGylated form of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095).1 It has been used in the generation of micelles and in combination with other lipids in the formation of liposomes. Liposomes containing DSPE-mPEG(2000) and encapsulating the DNA topoisomerase inhibitor doxorubicin (Item No. 15007) and the flavonoid quercetin (Item No. 10005169) reduce tumor growth in an MCF-7/adr multidrug-resistant breast cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, J., Luo, Y., Zhao, X., et al. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer. RSC Adv. 6(114), 113173–113184 (2016).