A perfluoroalkyl substance
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Perfluorobutanesulfonic Acid

Item No. 37243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonic acid
CAS Number
375-73-5
Synonyms
  • Eftop FBSA
  • Nonafluoro-1-butanesulfonic Acid
  • Nonafluorobutane-1-sulfonic Acid
  • Nonafluorobutanesulfonic Acid
  • PFBS
Molecular Formula
C4HF9O3S
Formula Weight
300.1
Purity
≥80%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=S(O)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)=O
InChi Code
InChI=1S/C4HF9O3S/c5-1(6,3(9,10)11)2(7,8)4(12,13)17(14,15)16/h(H,14,15,16)
InChi Key
JGTNAGYHADQMCM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Perfluorobutanesulfonic acid (PFBS) is a perfluoroalkyl substance (PFAS).1,2 It enhances oleic acid- and palmitic acid-induced lipid accumulation, an effect that can be reversed by the peroxisome proliferator-activated receptor γ (PPARγ) antagonist GW 9662 (Item No. 70785), and reactive oxygen species (ROS) production in HepG2 cells in an in vitro model of steatosis when used at a concentration of 200 µM.3 Prenatal exposure to PFBS is positively correlated with preterm birth.1 PFBS has been found as a contaminant in wastewater.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liao, Q., Tang, P., Song, Y., et al. Association of single and multiple prefluoroalkyl substances exposure with preterm birth: Results from a Chinese birth cohort study. Chemosphere 307(Pt 1), 135741 (2022).

    2. Kim, J., Xin, X., Mamo, B.T., et al. Occurrence and fate of ultrashort-chain and other per- and polyfluoroalkyl substances (PFAS) in wastewater treatment plants. ACS EST Water 2(8), 1380–1390 (2022).

    3. Qi, W., Clark, J.M., Timme-Laragy, A.R., et al. Perfluorobutanesulfonic acid (PFBS) induces fat accumulation in HepG2 human hepatoma. Toxicol. Environ. Chem. 102(10), 585-606 (2020).