A PEGylated derivative of DSPE
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DSPE-PEG(2000)-NHS ester

Item No. 37275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3-((((14-((2,5-dioxopyrrolidin-1-yl)oxy)-4,14-dioxo-5,8,11-trioxa-3-azatetradecyl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate
Molecular Formula
(C2H4O)nC51H93N2O15P
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: 5 mg/ml
SMILES
O=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCOCCC(ON1C(CCC1=O)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $103

    Add

    100 mg

    $194

    Add

    250 mg

    $457

    Add
    Cayman Chemical
    Visit Our Lipid Nanoparticle Resource Center for Additional Tools & Resources
    EXPLORE NOW
    Product Description

    DSPE-PEG(2000)-NHS ester is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095).1 It has been used in the generation of micelles and in combination with other lipids in the formation of liposomes. DSPE-PEG(2000)-NHS ester-containing liposomes localize to the liver and tumor after intravenous administration in mice. Liposomes containing DSPE-PEG(2000)-NHS ester conjugated to the breast cancer targeting H6 peptide and encapsulating the DNA topoisomerase inhibitor doxorubicin (Item No. 15007) reduce tumor growth in an SK-BR-3 breast cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jia, X., Wang, W., Han, Q., et al. Micromixer based preparation of functionalized liposomes and targeting drug delivery. ACS Med. Chem. Lett. 7(4), 429-434 (2016).