An oxylipin gut microbiota metabolite
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(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid

Item No. 37280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-hydroxy-12Z,15Z-octadecadienoic acid
CAS Number
34932-14-4
Synonyms
  • 12(Z),15(Z)-10-HODE
  • (±)-10-hydroxy-12(Z),15(Z)-ODE
Molecular Formula
C18H32O3
Formula Weight
296.5
Purity
≥98%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
SMILES
CC/C=C\C/C=C\CC(O)CCCCCCCCC(O)=O
InChi Code
InChI=1S/C18H32O3/c1-2-3-4-5-8-11-14-17(19)15-12-9-6-7-10-13-16-18(20)21/h3-4,8,11,17,19H,2,5-7,9-10,12-16H2,1H3,(H,20,21)/b4-3-,11-8-
InChi Key
WPPBDPYWQAWPCV-MLQKXRJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $61

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    1 mg

    $116

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    5 mg

    $484

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    Product Description

    (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic acid is an oxylipin. It is produced from α-linolenic acid (Item Nos. 90210 | 21910) by the gut bacteria L. plantarum.1 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic acid prevents increases in mRNA expression of the gene encoding SREBP-1c by the liver X receptor (LXR) agonist T0901317 (Item No. 71810) in HepG2 cells. It reduces LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages when used at a concentration of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nanthirudjanar, T., Furumoto, H., Zheng, J., et al. Gut microbial fatty acid metabolites reduce triacylglycerol levels in hepatocytes. Lipids 50(11), 1093-1102 (2015).

    2. Yang, H.-E., Li, Y., Nishimura, A., et al. Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes. Mol. Nutr. Food Res. 61(10), (2017).