An SGLT1 and SGLT2 inhibitor
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T-1095

Item No. 37284

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(5-benzofuranyl)-1-[2-hydroxy-6-[[6-O-(methoxycarbonyl)-β-D-glucopyranosyl]oxy]-4-methylphenyl]-1-propanone
CAS Number
209746-59-8
Molecular Formula
C26H28O11
Formula Weight
516.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
SMILES
O=C(CCC1=CC=C(OC=C2)C2=C1)C(C(O)=CC(C)=C3)=C3O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)COC(OC)=O
InChi Code
InChI=1S/C26H28O11/c1-13-9-17(28)21(16(27)5-3-14-4-6-18-15(11-14)7-8-34-18)19(10-13)36-25-24(31)23(30)22(29)20(37-25)12-35-26(32)33-2/h4,6-11,20,22-25,28-31H,3,5,12H2,1-2H3/t20-,22-,23+,24-,25-/m1/s1
InChi Key
BXNCIERBDJYIQT-PRDVQWLOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $140

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    50 mg

    $548

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    100 mg

    $802

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    T-1095 is an inhibitor of sodium-glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s = 22.8 and 2.3 µM, respectively).1 Dietary administration of T-1095 (0.01% w/w) reduces blood glucose and HbA1c levels in a rat model of diabetes induced by streptozotocin (Item No. 13104). It suppresses the development of hyperglycemia and hypertriglyceridemia and reduces HbA1c levels in the KKAγ mouse model of type 2 diabetes. T-1095 exacerbates post-infarction cardiac dysfunction in a rat model of left anterior descending coronary artery ligation-induced myocardial infarction.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oku, A., Ueta, K., Ishihara, T., et al. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes 48(9), 1794-1800 (1999).

    2. Bruno, J.G., Herman, T.S., Cano, V.L., et al. Selective cytotoxicity of 3-amino-L-tyrosine correlates with peroxidase activity. In Vitro Cell. Dev. Biol. Anim. 35(7), 376-382 (1999).