A vitamin D receptor antagonist
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MeTC7

Item No. 37338

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-acetic acid, (6S,8aR,8bR,10aR,11R,13aR)-11-[(1R)-1,5-dimethylhexyl]-2,3,5,6,7,8,8a,8b,10,10a,11,12,13,13a-tetradecahydro-2,8a,10a-trimethyl-1,3-dioxo-4a,13b-etheno-1H,9H-benzo[c]cyclopenta[h][1,2,4]triazolo[1,2-a]cinnolin-6-yl ester
CAS Number
1817841-22-7
Molecular Formula
C32H48BrN3O4
Formula Weight
618.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
SMILES
C[C@@]12[C@](C=C[C@@]34C2CC[C@@]5(C)[C@@]3([H])CC[C@]5([H])[C@@H](CCCC(C)C)C)(N6C(N(C)C(N64)=O)=O)C[C@@H](OC(CBr)=O)CC1
InChi Code
InChI=1S/C32H48BrN3O4/c1-20(2)8-7-9-21(3)23-10-11-24-29(23,4)14-13-25-30(5)15-12-22(40-26(37)19-33)18-31(30)16-17-32(24,25)36-28(39)34(6)27(38)35(31)36/h16-17,20-25H,7-15,18-19H2,1-6H3/t21-,22+,23-,24-,25?,29-,30-,31-,32+/m1/s1
InChi Key
LBFDLJSQMPCWKK-RBRUHCLLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    MeTC7 is a vitamin D receptor (VDR) antagonist (IC50 = 2.9 µM in a fluorescence polarization assay).1 It inhibits VDR transactivation in HEK293 cells (IC50 = 20.8 µM). It decreases the viability of OVCAR-8, OV-2008, SKOV3, Caov-3, and IGROV-1 ovarian cancer cells in a concentration-dependent manner. MeTC7 (250 nM) reduces retinoid X receptor α (RXRα) and importin-4 protein levels in OV-2008 cells. It decreases programmed cell death 1 ligand 1 (PD-L1) levels in primary human acute myeloid leukemia (AML) cells when used at a concentration of 500 nM.2 MeTC7 (10 mg/kg) reduces tumor growth in an SH-SY5Y neuroblastoma mouse xenograft model.1 Lipid nanoparticles (LNPs) containing MeTC7 selectively localize to the pancreas in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khazan, N., Kim, K.K., Hansen, J.N., et al. Identification of a vitamin-D receptor antagonist, MeTC7, which inhibits the growth of xenograft and transgenic tumors in vivo. J. Med. Chem. 65(8), 6039-6055 (2022).

    2. Khazan, N., Quarato, E.R., Singh, N.A., et al. Vitamin D receptor antagonist MeTC7 inhibits PD-L1. Cancers (Basel) 15(13), 3432 (2023).

    3. Isaac, I., Patel, L., Tran, N., et al. Reengineering endogenous targeting lipid nanoparticles (ENDO) for systemic delivery of mRNA to pancreas. Adv. Mater. 37(40), e2507657 (2025).