5,7-Dimethoxyflavone

5,7-Dimethoxyflavone (5,7-DMF) is a flavonoid that has been found in B. pandurata and has diverse biological activities.^1,2,3 It induces the production of reactive oxygen species (ROS), cell cycle arrest at the G₁ phase, and apoptosis in HepG2 liver cancer cells when used at concentrations of 10, 25, and 50 µM.² In vivo, 5,7-DMF (75-150 mg/kg) reduces exudate volume and inhibits prostaglandin production in a rat model of carrageenan-induced pleurisy.¹ It reduces rectal temperature in a rat model of yeast-induced hyperthermia. 5,7-DMF also reduces serum triglyceride, total cholesterol, and LDL levels, as well as increases serum insulin levels and reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).³

WARNING This product is not for human or veterinary use.

1. Panthong, A., Tassaneeyakul, W., Kanjanapothi, D., et al. Anti-inflammatory activity of 5,7-dimethoxyflavone. Planta Med. 55(2), 133-136 (1989).

2. Xie, Y., Zhang, Y., and Su, X. Antidiabetic and hypolipidemic effects of 5,7-dimethoxyflavone in streptozotocin-induced diabetic rats. Med. Sci. Monit. 25, 9893-9901 (2019).