An HCA2 antagonist
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Pro-drug Form(s)
37714Myristyl Nicotinate
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Nicotinic Acid

Item No. 37416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-pyridinecarboxylic acid
CAS Number
59-67-6
Synonyms
  • Niacin
  • NSC 169454
  • Pyridine-3-Carboxylic Acid
  • SR 4390
  • Vitamin B3
Molecular Formula
C6H5NO2
Formula Weight
123.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
217 nm
SMILES
O=C(C1=CN=CC=C1)O
InChi Code
InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChi Key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 g

    $33

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    500 g

    $60

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Nicotinic acid, also known as niacin, is an antagonist of hydroxycarboxylic acid receptor 2 (HCA2), known previously as GPR109A (Ki = 113 nM).1 Nicotinic acid reduces lipolysis in primary human adipocytes (IC50 = 200 nM).2 It reduces the invasion of AH109A-TC cancer cells when used at concentrations of 20 and 40 µM.3 Nicotinic acid increases cutaneous vasodilation in normotensive mice in a dose-dependent manner.4 Formulations containing nicotinic acid have been used in the treatment of hyperlipidemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tunaru, S., Kero, J., Schaub, A., et al. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9(3), 352-355 (2003).

    2. Ren, N., Kaplan, R., Hernandez, M., et al. Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G). J. Lipid Res. 50(5), 908-914 (2009).

    3. Hirakawa, N., Okauchi, R., Miura, Y., et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci. Biotechnol. Biochem. 69(3), 653-658 (2005).

    4. Cheng, K., Wu, T.J., Wu, K.K., et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc. Natl. Acad. Sci. USA 103(17), 6682-6687 (2006).