A peptide derivative of Tat-CBD3 with analgesic activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Peptides

Research Area

Neuroscience
Pain Research

Tat-CBD3A6K (trifluoroacetate salt)

Item No. 37449

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-alanyl-L-arginyl-L-seryl-L-arginyl-L-leucyl-L-lysyl-L-α-glutamyl-L-leucyl-L-arginylglycyl-L-valyl-L-prolyl-L-arginylglycyl-L-leucine, trifluoroacetate salt
Molecular Formula
C137H250N60O32 • XCF3COOH
Formula Weight
3249.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRARSRLKELRGVPRGL-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(O)C=C2)N[H]
InChi Code
InChI=1S/C137H250N60O32.C2HF3O2/c1-71(2)63-94(122(223)180-79(30-16-52-163-128(143)144)107(208)175-69-102(203)196-104(74(7)8)126(227)197-62-26-40-98(197)125(226)192-80(31-17-53-164-129(145)146)108(209)174-68-101(202)178-96(127(228)229)65-73(5)6)194-121(222)93(46-48-103(204)205)191-113(214)84(29-12-15-51-140)188-123(224)95(64-72(3)4)193-118(219)91(39-25-61-172-137(161)162)189-124(225)97(70-198)195-119(220)86(34-20-56-167-132(151)152)179-105(206)75(9)176-109(210)85(33-19-55-166-131(149)150)183-114(215)87(35-21-57-168-133(153)154)185-116(217)89(37-23-59-170-135(157)158)187-120(221)92(45-47-99(142)200)190-117(218)90(38-24-60-171-136(159)160)186-115(216)88(36-22-58-169-134(155)156)184-112(213)83(28-11-14-50-139)182-111(212)82(27-10-13-49-138)181-110(211)81(32-18-54-165-130(147)148)177-100(201)67-173-106(207)78(141)66-76-41-43-77(199)44-42-76;3-2(4,5)1(6)7/h41-44,71-75,78-98,104,198-199H,10-40,45-70,138-141H2,1-9H3,(H2,142,200)(H,173,207)(H,174,209)(H,175,208)(H,176,210)(H,177,201)(H,178,202)(H,179,206)(H,180,223)(H,181,211)(H,182,212)(H,183,215)(H,184,213)(H,185,217)(H,186,216)(H,187,221)(H,188,224)(H,189,225)(H,190,218)(H,191,214)(H,192,226)(H,193,219)(H,194,222)(H,195,220)(H,196,203)(H,204,205)(H,228,229)(H4,143,144,163)(H4,145,146,164)(H4,147,148,165)(H4,149,150,166)(H4,151,152,167)(H4,153,154,168)(H4,155,156,169)(H4,157,158,170)(H4,159,160,171)(H4,161,162,172);(H,6,7)/t75-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,104-;/m0./s1
InChi Key
ZJUHGWRQIDBISI-WGFCVTRASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $29

    Add

    5 mg

    $135

    Add

    10 mg

    $253

    Add

    25 mg

    $597

    Add
    Product Description

    Tat-CBD3A6K is a peptide and derivative of the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2) protein-protein interaction inhibitor Tat-CBD3 (Item No. 37448).1,2 Tat-CBD3A6K (10 mg/kg) prevents decreases in the paw withdrawal threshold in a rat model of antiretroviral neuropathic pain induced by d4T (stavudine; Item No. 14975) and decreases the number of action potentials from dorsal root ganglia (DRG) neurons isolated from the same rats.1 Dural administration of Tat-CBD3A6K decreases meningeal blood flow induced by the terpene alkaloid capsaicin (Item Nos. 92350 | 10010743) in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Piekarz, A.D., Rue, M.R., Khanna, M., et al. CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy. Mol. Pain. 8, 54 (2012).

    2. Wilson, S.M., Brittain, J.M., Piekarz, A.D., et al. Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. Channels (Austin) 5(5), 449-456 (2011).