A cell-penetrating peptide
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Product Type

Biochemicals
Peptides
Lipid Nanoparticles (LNPs)

Research Area

Transportan (trifluoroacetate salt)

Item No. 37497

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-lysyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-lysyl-L-alanyl-L-leucyl-L-alanyl-L-alanyl-L-leucyl-L-alanyl-L-lysyl-L-lysyl-L-isoleucyl-L-leucinamide, trifluoroacetate salt
Molecular Formula
C134H227N35O32 • XCF3COOH
Formula Weight
2840.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
GWTLNSAGYLLGKINLKALAALAKKIL-NH2
Solubility(Learn about Variance in Solubility)
10% ACN/H2O: soluble
SMILES
OC(C(F)(F)F)=O.[H]NCC(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)C)=O)=O)C)=O)C)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)C)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O
InChi Code
InChI=1S/C134H227N35O32.C2HF3O2/c1-25-74(17)108(132(199)157-91(111(142)178)51-67(3)4)168-121(188)90(42-32-36-50-138)155-119(186)89(41-31-35-49-137)154-114(181)79(22)150-123(190)94(54-70(9)10)158-115(182)78(21)146-113(180)77(20)149-122(189)93(53-69(7)8)159-116(183)80(23)148-118(185)88(40-30-34-48-136)156-124(191)95(55-71(11)12)162-128(195)101(61-104(141)174)165-133(200)109(75(18)26-2)167-120(187)87(39-29-33-47-135)151-106(176)65-145-117(184)92(52-68(5)6)160-125(192)96(56-72(13)14)161-127(194)98(58-82-43-45-84(172)46-44-82)153-107(177)64-144-112(179)76(19)147-131(198)102(66-170)166-129(196)100(60-103(140)173)163-126(193)97(57-73(15)16)164-134(201)110(81(24)171)169-130(197)99(152-105(175)62-139)59-83-63-143-86-38-28-27-37-85(83)86;3-2(4,5)1(6)7/h27-28,37-38,43-46,63,67-81,87-102,108-110,143,170-172H,25-26,29-36,39-42,47-62,64-66,135-139H2,1-24H3,(H2,140,173)(H2,141,174)(H2,142,178)(H,144,179)(H,145,184)(H,146,180)(H,147,198)(H,148,185)(H,149,189)(H,150,190)(H,151,176)(H,152,175)(H,153,177)(H,154,181)(H,155,186)(H,156,191)(H,157,199)(H,158,182)(H,159,183)(H,160,192)(H,161,194)(H,162,195)(H,163,193)(H,164,201)(H,165,200)(H,166,196)(H,167,187)(H,168,188)(H,169,197);(H,6,7)/t74-,75-,76-,77-,78-,79-,80-,81+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,108-,109-,110-;/m0./s1
InChi Key
GMWOHJFWANMDDV-SHULRAIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Transportan is a cell-penetrating peptide.1 It is composed of 12 amino acids corresponding to amino acids 1-12 of the neuropeptide galanin (Item No. 33139) linked by a lysine residue to the mast cell degranulating peptide mastoparan (Item No. 20240). Transportan has been used in the surface functionalization of liposomes for drug delivery in vitro and in vivo and for the delivery of fluorescent cargo in vitro.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shah, V.R., Shah, Y.D., and Athalye, M.N. Novel approaches in development of cell penetrating peptides. J. Appl. Pharm. Res. 9(1), 8-24 (2021).

    2. Patel, S.G., Sayers, E.J., He, L., et al. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Sci. Rep. 9(1), 6298 (2019).

    3. Li, Y.-X., Wang, N., Hasan, M.M., et al. Co-administration of transportan peptide enhances the cellular entry of liposomes in the bystander manner both in vitro and in vivo. Mol. Pharm. 19(11), 4123-4134 (2022).