A Bax inhibitor
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Bax Channel Blocker

Item No. 37538

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,6-dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol
CAS Number
335165-68-9
Synonyms
  • BAI1
Molecular Formula
C19H21Br2N3O
Formula Weight
467.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlEthanol: Slightly soluble
SMILES
BrC1=CC=C2C(C3=C(N2CC(CN4CCNCC4)O)C=CC(Br)=C3)=C1
InChi Code
InChI=1S/C19H21Br2N3O/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23/h1-4,9-10,15,22,25H,5-8,11-12H2
InChi Key
KUUJEXLRLIPQQJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $37

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    50 mg

    $172

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    100 mg

    $289

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    Product Description

    Bax channel blocker is an inhibitor of Bax.1 It binds to Bax in a cell-free assay (Kd = 15 µM) and inhibits Bax-mediated membrane permeabilization induced by the membrane-targeted death ligand tBID in a liposomal release assay (IC50 = 3.3 µM). Bax channel blocker inhibits apoptosis induced by TNF-α- and the protein synthesis inhibitor cycloheximide (Item No. 14126) in mouse embryonic fibroblasts (MEFs; IC50 = 1.8 µM). It also inhibits cell death induced by the Bax activator BTSA1 (Item No. 37305) in OCI-AML-3 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garner, T.P., Amgalan, D., Reyna, D.E., et al. Small-molecule allosteric inhibitors of BAX. Nat. Chem. Biol. 15(4), 322-330 (2019).