An AhR antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BAY-218

Item No. 37583

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-chlorophenyl)-2-(3-fluorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-3-oxo-4-pyridazinecarboxamide
CAS Number
2162982-11-6
Synonyms
  • BAY-2335218
Molecular Formula
C20H17ClFN3O3
Formula Weight
401.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
266 nm
SMILES
O=C1N(C2=CC(F)=CC=C2)N=C(C3=CC=C(C=C3)Cl)C=C1C(N[C@@H](C)CO)=O
InChi Code
InChI=1S/C20H17ClFN3O3/c1-12(11-26)23-19(27)17-10-18(13-5-7-14(21)8-6-13)24-25(20(17)28)16-4-2-3-15(22)9-16/h2-10,12,26H,11H2,1H3,(H,23,27)/t12-/m0/s1
InChi Key
RFGRNBWAUZSMBN-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $74

    Add

    10 mg

    $118

    Add

    25 mg

    $257

    Add

    50 mg

    $366

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    BAY-218 is an aryl hydrocarbon receptor antagonist (AhR; IC50 = 39.9 nM).1 Preincubation with BAY-218 (1 µM) decreases AhR nuclear translocation induced by aflatoxin B1 (Item No. 11293) in L-02 hepatocytes and TK6 lymphoblasts.2 BAY-218 (30 mg/kg), alone and in combination with an anti-PD-L1 antibody, reduces tumor growth in a CT26 colorectal cancer mouse xenograft model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmees, N., Gutcher, I., Irlbacher, H., et al. 3-Oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides. (2017).

    2. Chen, Y., Lu, Z., Li, B., et al. Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells. Toxicol. Lett. 373, 132-140 (2023).