A RIPK1 inhibitor
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Necrostatin-34

Item No. 37735

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[3-cyano-1,4,5,6-tetrahydro-4-(4-methylphenyl)-6-oxo-2-pyridinyl]thio]-N-2-thiazolyl-acetamide
CAS Number
375835-43-1
Synonyms
  • Nec-34
Molecular Formula
C18H16N4O2S2
Formula Weight
384.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
280 nm
SMILES
N#CC1=C(NC(CC1C2=CC=C(C)C=C2)=O)SCC(NC3=NC=CS3)=O
InChi Code
InChI=1S/C18H16N4O2S2/c1-11-2-4-12(5-3-11)13-8-15(23)21-17(14(13)9-19)26-10-16(24)22-18-20-6-7-25-18/h2-7,13H,8,10H2,1H3,(H,21,23)(H,20,22,24)
InChi Key
LOQIRQHGJVGIEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $68

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    5 mg

    $300

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    10 mg

    $531

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    25 mg

    $1,077

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    Product Description

    Necrostatin-34 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1; IC50 = 5.5 µM).1 It inhibits TNF-α-induced necroptosis in Jurkat cells lacking Fas-associated death domain protein (FADD) and L-929 cells (IC50s = 6.67 and 1.35 µM, respectively). Necrostatin-34 (10 µM) inhibits necroptosis induced by the chemical inducer of dimerization for FK506 binding protein (FKPB) fusion proteins AP20187 (Item No. 36808) and the pan-caspase inhibitor Z-VA-DL-D(OMe)-FMK (zVAD-FMK; Item No. 27421) in L-929 cells expressing an FKBP and RIPK1 fusion protein.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meng, H., Wu, G., Zhao, X., et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 7(1), 41 (2021).