An inhibitor of BET bromodomains
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Isomer(s)
24686AFN-1252
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ODM-207

Item No. 37757

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(3,5-dimethyl-4-isoxazolyl)-7-methoxy-3-methyl-1-(2-pyridinylmethyl)-2(1H)-quinolinone
CAS Number
1801503-93-4
Molecular Formula
C22H21N3O3
Formula Weight
375.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
λmax
213, 235, 331, 344 nm
SMILES
O=C1C(C)=CC2=C(N1CC3=CC=CC=N3)C=C(OC)C(C4=C(C)ON=C4C)=C2
InChi Code
InChI=1S/C22H21N3O3/c1-13-9-16-10-18(21-14(2)24-28-15(21)3)20(27-4)11-19(16)25(22(13)26)12-17-7-5-6-8-23-17/h5-11H,12H2,1-4H3
InChi Key
YVGWSVHZXWFLIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $351

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    25 mg

    $767

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    Cayman Chemical
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    Product Description

    ODM-207 is an inhibitor of bromodomain and extra terminal domain (BET) bromodomains. It reduces the proliferation of isolated human metastatic apocrine sweat gland cancer cells (IC50 = 1.99 µM).1 ODM-207, in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (Item No. 10621), decreases proliferation of, and induces DNA double-strand breaks in, isolated human metastatic apocrine sweat gland cancer cells deficient in partner and localizer of BRCA2 (PALB2; IC50 = 650 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mäkelä, R., Härmä, V., Fajardo, N.B., et al. Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma. Oncotarget 12(11), 1100-1109 (2021).