A DGK-α inhibitor
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(5Z,2E)-CU-3

Item No. 37770

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide
CAS Number
1815598-71-0
Molecular Formula
C16H12N2O4S3
Formula Weight
392.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/ml
λmax
419 nm
SMILES
O=S(NN1C(/C(SC1=S)=C/C=C/C2=CC=CO2)=O)(C3=CC=CC=C3)=O
InChi Code
InChI=1S/C16H12N2O4S3/c19-15-14(10-4-6-12-7-5-11-22-12)24-16(23)18(15)17-25(20,21)13-8-2-1-3-9-13/h1-11,17H/b6-4+,14-10-
InChi Key
YIUMXULORVBWLL-SPGDJUBISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $141

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    10 mg

    $248

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    25 mg

    $542

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    Product Description

    (5Z,2E)-CU-3 is an inhibitor of diacylglycerol kinase α (DGK-α; IC50 = 0.6 µM for the porcine enzyme).1 It is selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM). (5Z,2E)-CU-3 (5 µM) induces apoptosis in HeLa cervical and HepG2 liver cancer cells and enhances increases in IL2 mRNA expression in Jurkat T cells induced with concanavalin A (Item No. 14951).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, K., Kunii, N., Sakuma, M., et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J. Lipid Res. 57(3), 368-379 (2016).