A FATP1 inhibitor
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Arylpiperazine 5k

Item No. 38135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(5-fluoro-2-pyridinyl)-N-(4,5,6,7-tetrahydro-2-benzothiazolyl)-1-piperazineacetamide
CAS Number
1431945-95-7
Synonyms
  • DS22420314
Molecular Formula
C18H22FN5OS
Formula Weight
375.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: Slightly
SMILES
FC1=CC=C(N=C1)N2CCN(CC(NC3=NC(CCCC4)=C4S3)=O)CC2
InChi Code
InChI=1S/C18H22FN5OS/c19-13-5-6-16(20-11-13)24-9-7-23(8-10-24)12-17(25)22-18-21-14-3-1-2-4-15(14)26-18/h5-6,11H,1-4,7-10,12H2,(H,21,22,25)
InChi Key
ORQHHLPTMSGMQT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $105

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    25 mg

    $249

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    50 mg

    $414

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    Product Description

    Arylpiperazine 5k is an inhibitor of fatty acid transport protein 1 (FATP1; IC50 = 4.6 nM for the human protein).1 It reduces the accumulation of neutral and polar lipids in MDA-MB-231 breast cancer cells induced by linoleic acid (Item Nos. 90150 | 90150.1 | 21909) when used at a concentration of 12.5 µM.2 Arylpiperazine 5k (12.5 µM) decreases ATP (Item No. 14498) and BODIPY-palmitate (Item No. 26749) levels in BJAB human lymphoma cells with a deletion of CD37, which is also a negative regulator of fatty acid uptake, but not in wild-type BJAB cells.3 It induces cell death in MDA-MB-231, MCF-7, HCC1806, and BT474 human breast cancer cells when used at a concentration of 12.5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsufuji, T., Ikeda, M., Naito, A., et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg. Med. Chem. Lett. 23(9), 2560-2565 (2013).

    2. Mendes, C., Lopes-Coelho, F., Ramos, C., et al. Unraveling FATP1, regulated by ER-β, as a targeted breast cancer innovative therapy. Sci. Rep. 9(1), 14107 (2019).

    3. Peeters, R., Cuenca-Escalona, J., Zaal, E.A., et al. Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37. Nat. Commun. 13(1), 5371 (2022).