A ROCK2 inhibitor
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Alternative(s)
34682Chroman 1 (hydrochloride hydrate)
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Chroman 1

Item No. 38248

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide
CAS Number
1273579-40-0
Synonyms
  • (S)-Chroman 1
Molecular Formula
C24H28N4O4
Formula Weight
436.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
273, 300 nm
SMILES
CN(C)CCOC(C=C(C1=CNN=C1)C=C2)=C2NC([C@H]3CC4=CC(OC)=CC=C4OC3)=O
InChi Code
InChI=1S/C24H28N4O4/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29)/t18-/m0/s1
InChi Key
ROFMCPHQNWGXGE-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = <1 nM).1 It is selective for ROCK2 over protein kinase A (PKA) and Cdc42-binding kinase α (MRCKα; IC50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits the phosphorylation of myosin light-chain (MLC) in a cell-based assay (IC50 = <4 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Y.T., Vojkovsky, T., Fang, X., et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med. Chem. Commun. 2(1), 73-75 (2011).