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Promethazine-d3 (hydrochloride)

Item No. 38299

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,α-dimethyl-N-(methyl-d3)-10H-phenothiazine-10-ethanamine, monohydrochloride
CAS Number
1435933-86-0
Molecular Formula
C17H17D3N2S • HCl
Formula Weight
323.9
Purity
≥99% deuterated forms (d1-d3)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
CC(N(C([2H])([2H])[2H])C)CN1C2=C(C=CC=C2)SC3=CC=CC=C31.Cl
InChi Code
InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H/i2D3;
InChi Key
XXPDBLUZJRXNNZ-MUTAZJQDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Promethazine-d3 (Item No. 38299) is intended for use as an internal standard for the quantification of promethazine (Item Nos. 21331 | 22450) by GC- or LC-MS. Promethazine is categorized as a phenothiazine.1 It has been associated with misuse in conjunction with opioids or sedatives.1,2 Formulations containing promethazine have been used in the treatment of various allergy-related conditions, anesthesia- or surgery-related nausea and vomiting, and to induce sedation. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsay, M.E., Procopio, G., Anderson, B.D., et al. Abuse and intentional misuse of promethazine reported to US Poison Centers: 2002 to 2012. J. Addict. Med. 9(3), 233-237 (2015).

    2. Chiappini, S., Schifano, F., Corkery, J.M., et al. Beyond the 'purple drank': Study of promethazine abuse according to the European Medicines Agency adverse drug reaction reports. J. Psychopharmacol. 35(6), 681-692 (2021).