A polychlorinated dibenzodioxin
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1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin

Item No. 38597

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4,6,7,8-heptachloro-dibenzo[b,e][1,4]dioxin
CAS Number
35822-46-9
Synonyms
  • 1,2,3,4,6,7,8-HpCDD
  • PCDD 73
  • Polychlorinated Dibenzodioxin 73
Molecular Formula
C12HCl7O2
Formula Weight
425.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly soluble upon heating
SMILES
ClC1=C(Cl)C=C2OC3=C(C(Cl)=C(C(Cl)=C3Cl)Cl)OC2=C1Cl
InChi Code
InChI=1S/C12HCl7O2/c13-2-1-3-10(7(17)4(2)14)21-12-9(19)6(16)5(15)8(18)11(12)20-3/h1H
InChi Key
WCLNVRQZUKYVAI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $325

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    Product Description

    1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin (1,2,3,4,6,7,8-HpCDD) is a polychlorinated dibenzodioxin (PCDD).1 It induces the expression of the genes encoding the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1, as well as the aryl hydrocarbon receptor repressor (AhRR) in primary human peripheral blood lymphocytes and increases ethoxyresorufin-O-deethylase (EROD) activity, a marker of CYP1A1 activity, in isolated human peripheral blood lymphocytes in a concentration-dependent manner. 1,2,3,4,6,7,8-HpCDD (100 µg/kg) decreases the production of antibodies against sheep red blood cells in mice.2 Chronic administration of 1,2,3,4,6,7,8-HpCDD decreases the time to death and increases lung and liver tumorigenesis in rats.3 1,2,3,4,6,7,8-HpCDD has been found in freshwater fish, human breastmilk, and in the air near municipal waste incinerators.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Ede, K.I., Gaisch, K.P.J., van den Berg, M., et al. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol. Lett. 226(1), 43-52 (2014).

    2. Kerkvliet, N.I., and Brauner, J.A. Mechanisms of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD)-induced humoral immune suppression: Evidence of primary defect in T-cell regulation. Toxicol. Appl. Pharmacol. 87(1), 18-31 (1987).

    3. Rozman, K.K., Lebofsky, M., and Pinson, D.M. Chronic toxicity and carcinogenicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin displays a distinct dose/time toxicity threshold (c x t = k) and a life-prolonging subthreshold effect. Food Chem. Toxicol. 43(5), 729-740 (2005).

    4. Zacharewski, T., Safe, L., Safe, S., et al. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in-vitro enzyme induction activities. Environ. Sci. Technol. 23(6), 730-735 (1989).

    5. Takekuma, M., Saito, K., Ogawa, M., et al. Levels of PCDDs, PCDFs and Co-PCBs in human milk in Saitama, Japan, and epidemiological research. Chemosphere 54(1), 127-135 (2004).

    6. Hu, S.-W., ChangChien, G.-P., and Chan, C.-C. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere 55(4), 611-620 (2004).