A polychlorinated dibenzodioxin
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1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin

Item No. 38598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4,6,7,8,9-octachloro-dibenzo[b,e][1,4]dioxin
CAS Number
3268-87-9
Synonyms
  • NSC 37651
  • OCDD
  • PCDD 75
Molecular Formula
C12Cl8O2
Formula Weight
459.8
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Sparingly soluble
SMILES
ClC1=C(Cl)C(Cl)=C2OC3=C(C(Cl)=C(C(Cl)=C3Cl)Cl)OC2=C1Cl
InChi Code
InChI=1S/C12Cl8O2/c13-1-2(14)6(18)10-9(5(1)17)21-11-7(19)3(15)4(16)8(20)12(11)22-10
InChi Key
FOIBFBMSLDGNHL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $366

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    Product Description

    1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin is a polychlorinated dibenzodioxin (PCDD).1 It increases ethoxyresorufin-O-deethylase (EROD) activity, a marker of cytochrome P450 (CYP) isoform CYP1A1 activity, in isolated rat liver microsomes (ED50 = 750 µg/kg). 1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin (50 µg/kg) induces hepatic fatty vacuolization in rats. It has been found in animal feed, freshwater fish, ash/soil from open burn sites, and in the air near municipal waste incinerators.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Couture, L.A., Elwell, M.R., and Birnbaum, L.S. Dioxin-like effects observed in male rats following exposure to octachlorodibenzo-p-dioxin (OCDD) during a 13-week study. Toxicol. Appl. Pharmacol. 93(1), 31-46 (1988).

    2. Pajurek, M., Warenik-Bany, M., and Mikolajczyk, S. Feed as a source of dioxins and PCBs. Chemosphere 308(Pt 1), 136243 (2022).

    3. Zacharewski, T., Safe, L., Safe, S., et al. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in-vitro enzyme induction activities. Environ. Sci. Technol. 23(6), 730-735 (1989).

    4. Harnly, M., Stephens, R., McLaughlin, C., et al. Polychlorinated dibenzo-p-dioxin and dibenzofuran contamination at metal recovery facilities, open burn sites, and a railroad car incineration facility. Environ. Sci. Technol. 29(3), 667-684 (1995).

    5. Hu, S.-W., ChangChien, G.-P., and Chan, C.-C. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere 55(4), 611-620 (2004).