A dioxin-like polychlorinated dibenzofuran
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

1,2,3,4,7,8,9-Heptachlorodibenzofuran

Item No. 38618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
55673-89-7
Synonyms
  • 1,2,3,4,7,8,9-HpCDF
  • PCDF 134
Molecular Formula
C12HCl7O
Formula Weight
409.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble
SMILES
ClC1=C(Cl)C(Cl)=C2C3=C(C=C(C(Cl)=C3Cl)Cl)OC2=C1Cl
InChi Code
InChI=1S/C12HCl7O/c13-2-1-3-4(7(15)6(2)14)5-8(16)9(17)10(18)11(19)12(5)20-3/h1H
InChi Key
VEZCTZWLJYWARH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $299

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    1,2,3,4,7,8,9-Heptachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran (PCDF).1 It induces the expression of the genes encoding the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1, as well as the aryl hydrocarbon receptor repressor (AhRR) in primary human peripheral blood lymphocytes and increases ethoxyresorufin-O-deethylase (EROD) activity, a marker of CYP1A1 activity, in isolated human peripheral blood lymphocytes in a concentration-dependent manner. 1,2,3,4,7,8,9-Heptachlorodibenzofuran decreases the number of splenic plaque-forming cells, indicating immunosuppression, and increases hepatic microsomal aryl hydrocarbon hydroxylase (AHH) activity in mice induced with sheep red blood cells (ED50s = 12 and 700 nmol/kg, respectively).2 It has been found in human breastmilk and in the air near municipal waste incinerators.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Ede, K.I., Gaisch, K.P.J., van den Berg, M., et al. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol. Lett. 226(1), 43-52 (2014).

    2. Dickerson, R., Howie, L., Davis, D., et al. The structure-dependent effects of heptachlorodibenzofuran isomers in male C57BL/6 mice: Immunotoxicity and monooxygenase enzyme induction. Fundam. Appl. Toxicol. 15(2), 298-307 (1990).

    3. Tawara, K., Nishijo, M., Honda, R., et al. Effects of maternal dioxin exposure on newborn size at birth among Japanese mother-infant pairs. Environ. Health Prev. Med. 14(2), 88-95 (2009).

    4. Hu, S.-W., ChangChien, G.-P., and Chan, C.-C. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere 55(4), 611-620 (2004).