A dioxin-like polychlorinated dibenzofuran
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1,2,3,4,6,7,8,9-Octachlorodibenzofuran

Item No. 38624

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
39001-02-0
Synonyms
  • OCDF
  • PCDF 135
Molecular Formula
C12Cl8O
Formula Weight
443.8
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Toluene: slightly soluble
SMILES
ClC1=C(Cl)C(Cl)=C2C3=C(C(Cl)=C(C(Cl)=C3Cl)Cl)OC2=C1Cl
InChi Code
InChI=1S/C12Cl8O/c13-3-1-2-4(14)6(16)8(18)10(20)12(2)21-11(1)9(19)7(17)5(3)15
InChi Key
RHIROFAGUQOFLU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $332

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    Product Description

    1,2,3,4,6,7,8,9-Octachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran (PCDF).1 It induces a seven-fold increase in ethoxyresorufin-O-deethylase (EROD) activity, a marker of cytochrome P450 (CYP) isoform CYP1A1 activity, in mouse liver microsomes but not in skin or lung homogenates. 1,2,3,4,6,7,8,9-Octachlorodibenzofuran selectively accumulates and persists in the liver over adipose tissue in monkeys.2 It has been found in the soil near municipal waste incinerators, in freshwater fish, and in blood from individuals that lived near or in herbicide-sprayed regions.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. De Vito, M.J., Maier, W.E., Diliberto, J.J., et al. Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment. Fundam. Appl. Toxicol. 20(1), 125-130 (1993).

    2. Neubert, D., Wiesmüller, T., Abraham, K., et al. Persistence of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in hepatic and adipose tissue of marmoset monkeys. Arch. Toxicol. 64(6), 431-432 (1990).

    3. Harnly, M., Stephens, R., McLaughlin, C., et al. Polychlorinated dibenzo-p-dioxin and dibenzofuran contamination at metal recovery facilities, open burn sites, and a railroad car incineration facility. Environ. Sci. Technol. 29(3), 667-684 (1995).

    4. Zacharewski, T., Safe, L., Safe, S., et al. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in-vitro enzyme induction activities. Environ. Sci. Technol. 23(6), 730-735 (1989).

    5. Vu, T.S., Nishijo, M., Nishino, Y., et al. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in blood samples from historically herbicide-sprayed areas and rural and industrialized unsprayed areas in Vietnam. Chemosphere 326, 138331 (2023).